Predictive Value of Mid-luteal Serum Progesterone Levels in Egg Donation Cycles

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Completed

Conditions: Pregnancy

Treatments: Other: Progesterone 25-75; Other: Progesterone <25, >75

Study type: Observational

Funder types: Other

Identifiers

NCT02696694

1511-VLC-061-EL

IVI-EST-2015-01 (Other Identifier)

Details and patient eligibility

About

This study aims to investigate the impact of serum progesterone concentrations on the day of embryo transfer in egg donation cycles under hormonal replacement therapy. As secondary outcomes, the investigators will investigate if endometrial volume measured by three-dimensional (3D) ultrasound on the day of embryo transfer is related with progesterone levels and with chances of pregnancy.

Enrollment: 242 patients

Sex: Female

Ages: 25 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age<50 yo
• BMI < 30Kg/m2
• Hormonal replacement cycle
• Endometrial thickness >6.5 mm during proliferative phase
• Transfer of one or two blastocyst grade A-B according to ASEBIR

Exclusion criteria

• Uterine pathology
• Cryptozoospermia
• Severe implantation failure (>6 GQ embryos transferred without success)

Trial design

242 participants in 2 patient groups

P25-P75

Description:

serum progesterone between 25 and 75 percentile

Treatment:

Other: Progesterone 25-75

<P25 ó >P75

Description:

serum progesterone \<25 or \>75 percentile

Treatment:

Other: Progesterone <25, >75