Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Sohag University

Status: Not yet enrolling

Conditions: Diabetic Kidney Injury

Treatments: Diagnostic Test: serum uric acid level to plasma HDL-c level ratio (UHR)

Study type: Observational

Funder types: Other

Identifiers

NCT06349850

Soh-Med-24-03-06MS

Details and patient eligibility

About

An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Full description

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetic patients
• willing and agreed to be included in the study

Exclusion criteria

• Type 1 DM patients
• patients with active urinary sediment
• patients with glomerulonephritis
• patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
• patients with evidence of alternative kidney disease
• patients with history of kidney transplantation
• patients with end stage renal disease
• patients with family history of non diabetic forms of kidney disease
• patients with active malignancy
• patients with established hemolytic disease
• CKD patients requiring dialysis
• patients taking drugs that interfere with serum uric acid level
• patients taking drugs that alter serum lipids level
• pregnancy
• Refused to consent to this study

Trial design

100 participants in 3 patient groups

HbA1c level group

Description:

* well controlled diabetic group : HBA1c less than 7% * poorly controlled diabetic group : HBA1c equal to ore more than 7%

Treatment:

Diagnostic Test: serum uric acid level to plasma HDL-c level ratio (UHR)

UHR level group

Description:

median levels of UHR will be used to dichotomize the patients into groups of : * low UHR group * high UHR group

Treatment:

Diagnostic Test: serum uric acid level to plasma HDL-c level ratio (UHR)

DKI group

Description:

study population will be grouped into another two groups according to the presence of DKI: * patients with DKI * patients without DKI

Treatment:

Diagnostic Test: serum uric acid level to plasma HDL-c level ratio (UHR)