Predictive Value of Soluble CD146 in Glioblastoma Patients (MUCIGLIO-01)

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Enrolling

Conditions: Glioblastoma

Treatments: Other: plasma collection

Study type: Interventional

Funder types: Other

Identifiers

NCT06001281

ID RCB (Other Identifier)

RCAPHM23_0011

Details and patient eligibility

About

Glioblastoma is the most common malignant primary brain tumor with poor prognosis because of its diffusive and infiltrative nature. The FDA approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this anti-angiogenic reagent is frequent and fails to enhance patients' overall survival. The investigators previously identified one novel mechanism responsible for bevacizumab-resistance in CD146-positive glioblastoma (Joshkon et al. Acta Neuropathol Commun, 2022).

Now, the investigators objective is to prospectively monitor the soluble CD146 value in plasma from patients treated by bevacizumab for recurrent glioblastoma.

The investigators will collect plasma at baseline, before the first bevacizumab administration, before the second administration, at the time of first MRI evaluation and at progression. Plasma CD146 value will be analyzed by ELISA.

The investigators expect to confirm the correlation between soluble CD146 value in plasma and patient response to bevacizumab.

Enrollment: 55 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Adult patients with recurrent IDHwt glioblastoma
• Relapse after standard first line treatment (radio-chemotherapy)
• Candidate for bevacizumab treatment
• Able to be monitored by MRI
• KPS ≥ 60%
• Written signed consent form

Exclusion criteria

• Pregnancy or breast feeding
• Life expectancy less than 3 months
• Bevacizumab in first line treatment
• Other concomitant life-threatening disease
• Under legal protection

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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55 participants in 1 patient group

plasma collection

Other group

Description:

Plasma samples will be prospectively collected at relevant time points during patient treatment.

Treatment:

Other: plasma collection