Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring

Central South University

Status: Completed

Conditions: Sepsis

Treatments: Diagnostic Test: NIRS; Diagnostic Test: Sublingual microcirculation

Study type: Observational

Funder types: Other

Identifiers

NCT03859726

201902035

Details and patient eligibility

About

Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation

Full description

Fluid therapy for sepsis patients has always been a research hotspot. Early studies suggest that early goal-directed therapy (EGDT) can reduce mortality in patients with sepsis and septic shock, which is included in the guidelines. However, recent studies suggest that EGDT does not reduce mortality. This may be related to the fact that EGDT only pays attention to systemic circulation and neglects microcirculation.

In the past few decades, arterial blood pressure, blood lactic acid and other circulatory indicators have been the target of septic shock treatment, but normal systemic circulation does not mean normal tissue perfusion. Obstacles to tissue perfusion, oxygenation and microcirculation may still exist. At the same time, compared with systemic hemodynamic parameters, microcirculation parameters may play a stronger role in predicting the prognosis of sepsis patients. It is believed that the ideal goal of resuscitation therapy for sepsis should be based on whether microcirculation function has been restored or not.

Objective:to observe the success rate of microcirculation imaging and oxygen saturation of peripheral tissues in sepsis patients under the guidance of current guidelines and procedures. At the same time, we compared the predictive value of microcirculation indicators to the prognosis of septic shock patients.

Enrollment: 72 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients fullfilled the diagnostic criteria of Sepsis 3.0

Exclusion criteria

• Patients who were younger than 18 years old，
• pregnant women
• patients who had been admitted to the Intensive Care Unit(ICU for<24 h)

Trial design

72 participants in 2 patient groups

Compliance group

Description:

6hLC≥10% NIRS Sublingual microcirculation

Treatment:

Diagnostic Test: Sublingual microcirculation

Diagnostic Test: NIRS

Non compliance group

Description:

6hLC\<10%