Predictive Value of Venous Excess Ultrasound Score in Management of Cardiorenal Patients

Assiut University

Status: Not yet enrolling

Conditions: Cardio-Renal Syndrome

Treatments: Other: VExUS score; Drug: Diuretic Effect

Study type: Observational

Funder types: Other

Identifiers

NCT05368766

VExUS score in cardiorenal

Details and patient eligibility

About

To assess predictive value of venous excess ultrasound score in cardiorenal patient management

Full description

Cardiorenal syndrome encompasses a spectrum of disorders involving both the heart and kidneys in which acute or chronic dysfunction in 1 organ may induce acute or chronic dysfunction in the other organ.

Fluid overload is deleterious in critically ill patients; apart from increased mortality, it can cause end-organ damage, thereby increasing the incidence of acute kidney injury (AKI), length of stay in ICU, and duration of mechanical ventilation.

Elevation of central venous pressure is directly transmitted to the renal veins because venous vascular resistance is negligible. As the encapsulated kidney has little room to expand, venous congestion causes renal interstitial hydrostatic pressure to increase. Furthermore, as the post-glomerular vascular and tubular network is a low-pressure system , the increase in the renal interstitial pressure causes compression or even occlusion of renal tubules. That in turn results in reduction or even shut down of tubular flow and shut down in the glomerular filtration .

The venous excess ultrasound (VExUS) score incorporates hepatic venous, intrarenal venous Doppler, inferior vena cava (IVC) assessment, and portal vein Doppler. By utilizing multiple parameters, the negative aspects of individual parameters might get negated and could be considered as a reliable tool to assess congestion of kidneys.

The investigators hypothesise that VExUS score could be valuable in predicting cardiorenal patients who need ultrafiltration in ICU. In this study the investigators will use VEXSUS score to predict response to diuretic therapy, to evaluate patients' volume status, and to predict mortality in cardiorenal patient

Every patient will be subjected to

1. Medical history taking.

2. Complete physical examination.

3. Routine laboratory investigations including baseline urea, creatinine, electrolytes, urine analysis, complete blood count, coagulation profile, liver functions test, arterial blood gas, serum lactate and daily follow up urea, creatinine, and electrolytes.

4. ECG, echocardiography, and lung ultrasound.

5. Volume status will be assessed by urine output, CVP, mean arterial pressure.

6. The following work up.

   • VExUS score (IVC assessment, hepatic venous, intrarenal venous Doppler and portal vein Doppler)
   • Cardiorenal patient will receive diuretic therapy as a standard treatment in patients with VEXSUS score 1-3
   • Daily VExUS score will be done
   • Diuretic resistance will be defined as failure to produce 0.5 ml/kg/h of urine after administration of at least double the dose of the patient's home diuretic therapy or after administration of 250 mg of Lasix and 10 mg of Metolazone in diuretic naïve patient).

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with congestive heart failure and GFR less than 100 ml/minute

Exclusion criteria

• Patients below 18 years old. Patients with liver cirrhosis and portal hypertension. Patients with IVC thrombus. Patients with inadequate ultrasonography window.