Predictive Values of Preoperative [68Ga]Ga-PSMA-11 PET/CT in Patients With Suspected Brain Tumours of Glial Origin

Medical University of Warsaw

Status: Completed

Conditions: Glioma, Malignant; Glioma Glioblastoma Multiforme

Treatments: Diagnostic Test: [68Ga]Ga-PSMA-11 PET/CT

Study type: Interventional

Funder types: Other

Identifiers

NCT05896449

WUM-ZMN-05-2023

Details and patient eligibility

About

The aim of this study was to analyse usefulness of [68Ga]Ga-PSMA-11 PET/CT scans in preoperative differentiation between HGG and LGG in patients with suspicion of a tumor of glial origin in previously performed imaging examinations. The PET/CT scan will be compared with postoperative histopathological results and with additional immunohistochemical staining for PSMA expression.

Enrollment: 49 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary lesion found in CT/MRI with radiological features of glial neoplasm
• untreated disease, planned surgery
• negative medical history of other neoplastic diseases
• age over 18
• informed, voluntary consent to participate in the study

Exclusion criteria

• pregnant women, breastfeeding women
• persons with a known allergy to PSMA
• age under 18
• patient's lack of cooperation

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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49 participants in 1 patient group

PET/CT before surgery

Experimental group

Description:

\[68Ga\]Ga-PSMA-11 PET/CT before surgery

Treatment:

Diagnostic Test: [68Ga]Ga-PSMA-11 PET/CT