Predictors and Outcomes of Dysglycemia in Pheochromocytoma and Paraganglioma

National Center for Cardiovascular Diseases

Status: Active, not recruiting

Conditions: Paraganglioma; Pheochromocytoma

Treatments: Other: Catecholamines

Study type: Observational

Funder types: Other

Identifiers

NCT05451134

2022-06

Details and patient eligibility

About

The investigators will retrospectively analyze the clinical data of consecutive patients with pheochromocytomas and paragangliomas admitted between January 2018 and June 2020. The clinical characteristics of patients with and without dysglycemia will be compared, and whether surgery could improve the patients'dysglycemia will be also investigated.

Full description

This retrospective cohort study will include all consecutive adult patients who underwent surgery for PHEOs and catecholamine-secreting PGLs from January 2018 to June 2020. Patients with recurrent PPGLs, those who required steroids after adrenalectomy, and those with inadequate clinical records were excluded. The patients' electronic medical files were reviewed. Patients with dysglycemia included those with diabetes, or impaired fasting glucose, or impaired glucose tolerance. Clinical history data such as age, sex, body mass index (BMI), the presence of preoperative symptoms, biochemical test results, and tumor characteristics, such as tumor diameters and locations were extracted and analyzed.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years old
• patients with surgical pathological diagnosis of pheochromocytomas and paragangliomas(PPGLs)

Exclusion criteria

• recurrent PPGLs
• patients who required steroids after adrenalectomy
• patients with inadequate clinical records were excluded.

Trial design

300 participants in 2 patient groups

patients with dysglycemia

Description:

Patients with dysglycemia in the included subjects with pheochromocytoma and paraganglioma

Treatment:

Other: Catecholamines

patients without dysglycemia

Description:

Patients without dysglycemia in the included subjects with pheochromocytoma and paraganglioma

Treatment:

Other: Catecholamines