Predictors for Low Rates of Surgical Resection in Elderly Patients With Resectable Pancreatic Ductal Adenocarcinoma

Fudan University

Status: Completed

Conditions: Pancreatic Ductal Adenocarcinoma

Treatments: Other: potential predictors

Study type: Observational

Funder types: Other

Identifiers

NCT06344299

HuaDong Hosiptal of FUDAN

Details and patient eligibility

About

More and more older adults are diagnosed with pancreatic ductal adenocarcinoma (PDAC), but the rate of surgical resection in patients with resectable tumour is still low. Clinical workers need to take more attention to oncologic care in this group. It's significant to explore potential predictors for impacting elderly patients chose to abandon surgical resection.

Full description

The incidence of pancreatic ductal adenocarcinoma (PDAC) in the elderly has been on the rise, but the elderly were always neglected in clinical oncology care. Pancreatic ductal adenocarcinoma is a lethal disease, and the most effective treatment for curing it remains the radical resection. Unfortunately, there are many a study had reported that the rate of radical surgery of patients with PDAC has been low in the past decade. In order for more elderly pancreatic cancer patients to undergo surgical resection, investigators extracted the data of elderly patients with PDAC from SEER program and investigated predictive factors associated with surgical resection abandonment. In this study, investigators extracted data of patients older than 75 years diagnosed with T1-T3 stage PDAC to investigate rate of radical surgery. And researchers used Univariate and multivariate logistic regression model to explore potential factors associated with patients and surgeon chose to abandon surgical resection.

Enrollment: 5,302 patients

Sex: All

Ages: 75 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients older than 75 years old and were diagnosed with pancreatic ductal adenocarcinoma by positive histology.
2. Patients were diagnosed with T1 through T3, M0 tumor based on criteria of TNM stage.

Exclusion criteria

1. Patients were diagnosed by death certificate.
2. Patients died before radical surgery.
3. Patients with important data missing, such as T-stage, surgical resection status, surgery procedures and complete survival time.

Trial design

5,302 participants in 2 patient groups

group of undergoing radical surgery

Description:

Elderly patients diagnosed with resectable PDAC underwent radical surgery.

group of abandoning radical surgery

Description:

Elderly patients diagnosed with resectable PDAC abandoned radical surgery, the reasons of treatment abandonment included surgeons didn't recommend surgery for their elderly patients and patients chose to refuse surgery.

Treatment:

Other: potential predictors