Predictors of Anticoagulation Control on Warfarin Therapy

University of Pennsylvania

Status: Completed

Conditions: Heart Valve Replacement; Atrial Fibrillation; Deep Vein Thrombosis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00905177

700902

Details and patient eligibility

About

The goal of this research study is to develop better dosing of anticoagulation medication in both Caucasian and African Americans through analysis of various genetic factors.

Full description

This is a prospective cohort study among adult patients requiring warfarin therapy. Patients presenting for anticoagulation will be identified at the start of therapy and followed throughout their course until they reach maintenance dose. We will then develop a dosing equation for warfarin using patient, environmental and genetic factors.

Enrollment: 687 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All Caucasians and African Americans who are new to warfarin therapy

Exclusion criteria

• Under 21 years of age
• Non caucasian
• Non african american
• Have an abnormal INR before warfarin or heparin therapy
• Unable to provide consent