Predictors of Cord Blood Immunoglobin E (IgE) Levels

Min-Sheng General Hospital

Status: Unknown

Conditions: Atopy

Study type: Observational

Funder types: Other

Identifiers

NCT00902096

2009008

Details and patient eligibility

About

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.

Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.

Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.

Enrollment: 800 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mothers in pregnancy 18 years of age or older, AND
• Mothers able to speak Chinese.

Exclusion criteria

• Infant delivered at less than 36 weeks' gestation,
• Infant with Apgar score in 5 minutes after birth < 7,
• Infant with a major congenital anomaly, OR
• Infant admitted to an intensive care unit.

Trial design

800 participants in 1 patient group

Prenatal factors

Description:

Prenatal factors to predict cord blood IgE