Predictors of Early Chest Infection in Acute Ischemic Stroke (PRECAST)

University of Rostock

Status: Completed

Conditions: Pneumonia; Acute Ischemic Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT00906542

PRECAST-01

Details and patient eligibility

About

Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.

Enrollment: 530 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute ischemic stroke
• admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset
• clearly assessed brain lesion location

Exclusion criteria

• previous large (non-lacunar) stroke
• chest infection present already on hospital admission
• mechanical ventilation already on day 1 or 2 after hospital admission
• treatment with immunosuppressive drugs

Trial design

530 participants in 1 patient group

Acute ischemic stroke patients

Description:

Acute ischemic stroke patients admitted to the neurological intensive care unit or stroke unit within 24 hours after stroke onset in whom ischemic brain lesion was clearly assessed on CT and/or MRI