Predictors of Myasthenia Gravis Outcome Following Thoracoscopic Thymectomy: Comparative Study Between Thymomatous and Non-Thymomatous Patients

Tanta University

Status: Completed

Conditions: Predictor; Myasthenia Gravis; Non-Thymomatous; Thoracoscopic Thymectomy; Thymomatous

Treatments: Other: Data collection

Study type: Observational

Funder types: Other

Identifiers

NCT07319689

36264PR13103/10/25

Details and patient eligibility

About

This study aimed to assess and compare predictors of outcome in patients with thymomatous and non-thymomatous MG undergoing Thoracoscopic thymectomy.

Full description

Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder characterized by fluctuating muscle weakness resulting from antibodies that target acetylcholine receptors or associated proteins at the neuromuscular junction.

Thoracoscopic thymectomy becomes more prominent than traditional transsternal thymectomy due to fewer perioperative complications with shorter hospital stays and more favorable long-term outcomes.

Prognostic outcomes following thoracoscopic thymectomy can vary significantly between non-thymomatous and thymomatous MG, necessitating a thorough investigation of these differences.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both sexes.
• Confirmed diagnosis of Myasthenia Gravis (MG).
• Underwent Thoracoscopic thymectomy.
• Availability of complete preoperative and postoperative records, including imaging and histopathology.
• Minimum follow-up of 9 months post-surgery.

Exclusion criteria

• Patients who underwent thymectomy for indications other than MG.
• Incomplete medical records or loss to follow-up before outcome assessment.
• Patients with concomitant neuromuscular disorders other than MG

Trial design

100 participants in 2 patient groups

Thymomatous Myasthenia Gravis group

Description:

Thymomatous myasthenia gravis (patients with histologically confirmed thymoma).

Treatment:

Other: Data collection

Non-thymomatous Myasthenia Gravis group

Description:

Non-thymomatous myasthenia gravis (patients with thymic hyperplasia or normal/ involuted thymus).

Treatment:

Other: Data collection