Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass

Alexandria University

Status: Not yet enrolling

Conditions: Cardiac Surgery; Cardio-pulmonary Bypass; Clinical Outcomes

Treatments: Procedure: cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass; Procedure: CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS

Study type: Interventional

Funder types: Other

Identifiers

NCT07034716

0108887

Details and patient eligibility

About

In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients. Many studies highlighted the potential role of hyperlactatemia on admission to the ICU as a marker for adverse outcome, and one study linked hyperlactatemia during CPB with postoperative morbidity and mortality. Evidence that both CENTRAL VENOUS SATURATION (ScVO2) and blood lactates during CPB are potential early predictors of morbidity and mortality in adult cardiac operations are still lacking.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

cardiac surgical patients who will undergo isolated elective CABG and fulfill these criteria:

1. Aged 18 years or above.
2. Operated with cardiopulmonary bypass.

Exclusion criteria

1. Preoperative lactate level greater than 3 mmol/l.
2. Redo surgery.
3. If the patient will be reoperated during the study time.
4. Preoperative hemoglobin level less than 10 mg/dl.
5. Ejection fraction (EF) of <30%.
6. Renal impairment.
7. Liver impairment.
8. History of stroke and significant carotid artery stenosis.
9. Chronic obstructive or restrictive lung disease.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Group (P): Pulsatile flow will be used during CPB

Experimental group

Description:

Pulsatile flow will be used during CPB

Treatment:

Procedure: cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass

Group NP: non-pulsatile perfusion.

Active Comparator group

Description:

non-pulsatile perfusion during CARDIOPULMONARY BYPASS

Treatment:

Procedure: CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS