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Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis

Cairo University (CU) logo

Cairo University (CU)

Status

Completed

Conditions

Hypersensitivity Pneumonitis
Pulmonary Hypertension

Treatments

Procedure: Right heart catheter

Study type

Interventional

Funder types

Other

Identifiers

NCT05458635
MS-131-2019

Details and patient eligibility

About

Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated immuneresponse. Hypersenstivity pneumonitis is a common form of diffuse parenchymal lung diseases in Egypt .Pulmonary hypertension has been found as a complication of a number of diseases affecting the lung interstitium, including hypersensitivity pneumonitis, with subsequent affection of the life expectancy Rationale of the study: to find predictors for the development of pulmonary hypertension in patients with hypersensitivity pneumonitis

Full description

Cross sectional study included 60 patients with established diagnosis of HP , work up includes history of exposure, clinical examination, HRCT chest, ABGs,6MWD, desaturation degree , spirometry, echocardiography and right heart catheter in patients with high echo probability of PH.

Enrollment

60 patients

Sex

All

Ages

29 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All patients with confirmed diagnosis of Hypersensitivity pneumonitis

Exclusion criteria

  • Other interstitial lung diseases

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

60 participants in 2 patient groups

HP without Pulmonary hypertion
No Intervention group
Description:
HRCT chest , pulmonary functions and echocardiography
HP with Pulmonary hypertion
Active Comparator group
Description:
HRCT chest , pulmonary functions ,echocardiography and RT heart catheter in high echocardiographic probability of PH
Treatment:
Procedure: Right heart catheter

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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