Predictors of Respiratory Failure in SARS-Cov-2 Infection

University of Bologna

Status: Unknown

Conditions: SARS-CoV-2 Pneumonia

Study type: Observational

Funder types: Other

Identifiers

NCT04316949

PREDI-CO

Details and patient eligibility

About

The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with SARS-CoV-2 pneumonia.

A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need ICU admission and/or those who may benefit from a prompt antiviral therapy

Full description

The study will compared patients with and without respiratory failure in order to find risk factors for need for ICU admission. A simple score based on risk factors will be created from a multicenter Italian cohort and validated in a multicenter international cohort.

Enrollment: 350 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalized patients with microbiologically confirmed diagnosis of SARS-CoV-2 infection
• Age > 17 years

Exclusion criteria

• Invasive mechanical ventilation within 12 hours from hospital admission

Trial design

350 participants in 2 patient groups

Derivation cohort

Description:

Derivation cohort: Italian retrospective cohort of all consecutive hospitalized patients with SARS-CoV-2 pneumonia in the participating centers, from February 20 to March 19 2020. .

Validation cohort

Description:

Validation cohort: European and non-European retrospective cohort of all consecutive hospitalized patients with SARS-CoV-2 pneumonia in the participating centers, from March 19 to April 18 2020.