Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

Mass General Brigham

Status: Unknown

Conditions: Critically Ill; Obstructive Sleep Apnea

Treatments: Drug: Sedatives and muscle relaxants given in the ICU; Other: Pulmonary function test; Other: Grip strength measurement; Device: Alice PDx; Other: Muscle strength tests; Device: Ventilator

Study type: Observational

Funder types: Other

Identifiers

NCT02112604

2010P001919B

Details and patient eligibility

About

This is part 2 of the #NCT01618240 under the same IRB protocol #2010P001919. The primary objective of this study is to examine factors that are related to sleep-disordered breathing and upper airway patency in critically ill patients who have been recently mechanically ventilated. Our primary hypothesize is that sedatives and neuromuscular blocking agents given in the ICU prior to extubation and during the first night following extubation are associated with sleep-disordered breathing. The secondary hypotheses are that duration of mechanical ventilation, BMI, and muscle strength are associated with sleep-disordered breathing during the night after extubation.

The secondary objective is to evaluate if sleep-disordered breathing in the ICU can be predicted by standard pulmonary function testing in the ICU.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients admitted to the SICU
2. Age over 18 years.
3. Ventilated patients with an endotracheal tube for at least 24 hours.

Exclusion criteria

1. Decreased level of consciousness as defined by a Richmond Agitation Sedation Scale (RASS) of 0.
2. Non-cooperative patient, CAM score positive for risk of delirium.
3. For women: pregnancy.

Trial design

50 participants in 1 patient group

Ventilated patients

Description:

Patients who have been extubated within 24 hours and have been mechanically ventilated for at least 24 hours. Alice PDx, pulmonary function tests, muscle strength tests, grip strength measurements, ventilator, Sedatives and muscle relaxants given in the ICU

Treatment:

Other: Pulmonary function test

Other: Grip strength measurement

Device: Alice PDx

Other: Muscle strength tests

Device: Ventilator

Drug: Sedatives and muscle relaxants given in the ICU