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About
This project aims at investigating the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related end organ damage (renal damage and heart failure). It will include cross sectional as well as follow-up studies with a large number of subjects and variety of phenotypes, to explore the pathophysiology of hypertension and hypertension-related disease.
Full description
In all index patients and recruited family members, recorded data will include the following :
Past medical history, drug history and family history Physical examination Height, weight, waist and hip circumference Cardiac examination Vascular examination Blood pressure Plasma and urine samples Body composition (DEXA) Tissue Doppler imaging
Enrollment
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Inclusion criteria
index patient :
Caucasian patients of either sex who were diagnosed to have essential hypertension (as defined below) before the age of 50 y.
The index patient should not be older than 60 years at the time of enrolment.
Definition of hypertension for the index patient:
At least three first degree relatives of whom at least one should be affected and at least one be from a different generation (parents or offspring aged 18 years or above) must be willing to participate in the family study. For definition of hypertension in relatives of the index patient see below.
Written informed consent
family
Exclusion criteria
index patient :
family
60 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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