Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects

ASST Gaetano Pini-CTO

Status: Completed

Conditions: Chronic Pain

Study type: Observational

Funder types: Other

Identifiers

NCT01989351

IOGPGC03-13

Details and patient eligibility

About

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS>4 patients and to compare it to those with VAS<4.

Enrollment: 130 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18
• ASA I to III

Exclusion criteria

• Contraindications to regional anesthesia procedures
• Not stabilized neurological diseases
• Diabetes

Trial design

130 participants in 2 patient groups

VAS<4

VAS>4