Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache

Sorlandet Hospital HF

Status and phase: Completed; Phase 3

Conditions: Headache

Treatments: Drug: prednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT00135122

70203

Details and patient eligibility

About

The purpose of this study is to determine whether prednisolone is more effective than placebo in the first six days after initiation of medication withdrawal therapy for a medication overuse headache. Another purpose is to study whether patients followed by a neurologist 1 year after withdrawal do better than patients followed by a general practitioner.

Full description

Data published BoeMG,Mygland A,Salvesen R; Neurology 2007 Jul 3;69(1):26-31

Enrollment: 100 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic daily headache and medication overuse fulfilling International Headache Society (IHS)-II criteria

Exclusion criteria

• Pregnancy
• Age under 18 and over 70 years
• Major mental disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 1 patient group, including a placebo group

2

Placebo Comparator group

Description:

Placebo in six days

Treatment:

Drug: prednisolone