Prednisone for Heart Failure Patients With Hyperuricemia

Hebei Medical University

Status and phase: Completed; Phase 4

Conditions: Hyperuricemia; Heart Failure

Treatments: Drug: allopurinol; Drug: prednisone

Study type: Interventional

Funder types: Other

Identifiers

NCT00919243

hebmu 08-12

Details and patient eligibility

About

Hyperuricemia is a very common finding in patients with heart failure. It is usually related to diuretic use and deteriorated renal function. The recently evidence showed that uric acid (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could dramatically lower UA while improving renal function. Thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering UA and could improve renal function at the same time.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-70 years old
• NYHA Class III-IV
• EF =< 40%
• Uric acid => 9.5 mg/dL

Exclusion criteria

• Acute gouty arthritis
• Any condition (other than CHF) that could limit the use of prednisone or allopurinol
• Any concurrent disease likely to limit life expectancy.
• Active myocarditis, or an obstructive or restrictive cardiomyopathy
• Heart Attack, Stroke, Unstable Angina or Cardiac surgery within previous 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

prednisone

Experimental group

Treatment:

Drug: prednisone

allopurinol

Active Comparator group

Treatment:

Drug: allopurinol