Preemptive Analgesia in Cruciate Reconstruction

Prince of Songkla University

Status and phase: Completed; Phase 3

Conditions: Anterior Cruciate Ligament Injury

Treatments: Drug: etoricoxib; Drug: Celecoxib

Study type: Interventional

Funder types: Other

Identifiers

NCT01017380

EC50/369-007

Details and patient eligibility

About

The aims of this study was to compare analgesic efficacy of preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction. One hundred and two patients diagnosed as anterior cruciate ligament injury will randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients will be operated by one orthopaedic surgeon under regional anesthesia. Each group will be given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for rescue pain control and adverse events will be recorded periodically to 48 hours after surgery.

Enrollment: 30 patients

Sex: All

Ages: 15 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with anterior cruciate ligament injury age 15-50 yr

Exclusion criteria

• previous knee surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 1 patient group

placebo

Experimental group

Description:

identical placebo

Treatment:

Drug: Celecoxib

Drug: etoricoxib