Preemptive Analgesia With Morphine Sulphate in Major Urological Surgery

University of Roma La Sapienza

Status: Unknown

Conditions: Pain

Study type: Observational

Funder types: Other

Identifiers

NCT02041988

1846/08.04.10

Details and patient eligibility

About

In this study safety and efficacy of oral morphine sulphate is evaluated in order to reduce opioids administration during major urological surgery

Full description

The administration of oral morphine sulfate could be useful to reduce the use of opioids in major urological surgery. This study aims to assess the safety and efficacy of two different oral morphine sulphate doses 0,2 mg/kg vs 0,4mg/kg in major urological surgery.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

American Society of Anaesthesiologists physical status classification I/ II, age between 18 - 75, BMI 18 -30

Exclusion criteria

American Society of Anaesthesiologists physical status classification III/ IV, renal and hepatic insufficiency, postoperative nausea and vomiting after oral opioids administrations, neurological and psychiatric disorders.

Trial design

40 participants in 2 patient groups

0,2 mg/kg oral morphine

Description:

Patients have been assigned to two groups of 20 individuals, they have been premedicated with oral morphine sulfate, 0,2 mg/kg group A, 0,4mg/kg group B.During surgery analgesic administration will be monitored

0,4 mg/ kg oral morphine

Description:

morphine and analgesic consumption throughout surgery will be monitored