Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain

Seoul National University

Status: Completed

Conditions: Chronic Post-thoracotomy Pain

Treatments: Drug: ketamine free; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT01017393

JHBahk_epidural ketamine PTPS

Details and patient eligibility

About

Chronic post-thoracotomy pain is the most common long-term complication that occurs after a thoracotomy with a reported incidence of up to 80%. While thoracic epidural analgesia has become the mainstay for managing acute post-thoracotomy pain, its effect on the chronic post-thoracotomy pain seems questionable. The objective of this prospective, double-blinded, randomized, controlled trial was to assess the effect of preemptive low-dose epidural ketamine in addition to preemptive thoracic epidural analgesia on the incidence of chronic post-thoracotomy pain.

Enrollment: 209 patients

Sex: All

Ages: 19 to 81 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing surgery with a thoracotomy incision

Exclusion criteria

• history of previous thoracic surgery, chronic pain, psychiatric disease, cardiac or vascular disease, neurologic deficits, or contraindications to epidural catheterization such as coagulopathy, or localized or systemic infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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209 participants in 2 patient groups

ketamine

Experimental group

Description:

epidural ketamine added to the patient controlled epidural analgesia regimen

Treatment:

Drug: Ketamine

ketamine free

Active Comparator group

Description:

epidural ketamine NOT added to the patient controlled epidural analgesia regimen

Treatment:

Drug: ketamine free