Preemptive Lung Impedance-Guided Therapy in Evolving Acute Heart Failure in Acute Myocardial Infarction Patients

Hillel Yaffe Medical Center

Status and phase: Completed; Phase 3

Conditions: Heart Failure

Treatments: Other: Usual treatment of patients with developing acute heart failure; Device: Lung Impedance-Guided Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01616121

0037-12-HYMC

Details and patient eligibility

About

It is well-known that 20-25% of patients hospitalized for acute myocardial infarction will develop acute heart failure during their hospitalization. Currently, the investigators have no reliable parameter for prediction of evolving acute heart failure in such a group of patients. As a result, the investigators have no way of preventing acute heart failure. Treatment of these patients only begins after appearance of clinical signs of acute heart failure. Lung impedance monitoring may be a good non-invasive parameter for prediction of evolving acute heart failure. This study will attempt to address whether preemptive lung impedance-guided therapy may prevent the development of overt acute heart failure and improve their clinical outcome.

Enrollment: 654 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients hospitalized in the ICCU for acute myocardial infarction and developing acute heart failure

Exclusion criteria

• Patients with acute myocardial infarction with clinical and radiological signs of acute heart failure at admission

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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654 participants in 2 patient groups

Conventional Treatment Heart Failure

Active Comparator group

Description:

Conventional Treatment

Treatment:

Other: Usual treatment of patients with developing acute heart failure

Lung Impedance-Guided Therapy

Experimental group

Description:

Lung Impedance-Guided Therapy

Treatment:

Device: Lung Impedance-Guided Therapy