Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy

Tanta University

Status: Not yet enrolling

Conditions: Postoperative Pain; Gabapentin; Spinal Anesthesia; Knee Arthroscopy; Tramadol

Treatments: Drug: Gabapentin; Drug: Tramadol

Study type: Interventional

Funder types: Other

Identifiers

NCT06112223

36264PR151/3/23

Details and patient eligibility

About

The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.

Full description

Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic.

Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics.

Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety.

Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-65 years old.
• Both sexes. American Society of Anesthesiologists (ASA) physical status I and II
• Undergoing knee arthroscopy procedures.
• under spinal anesthesia.

Exclusion criteria

• Cardiac patients.
• Patients with known allergy to drug of study.
• Prolonged administration of NSAIDS or other analgesics due to chronic pain of any reason.
• Cirrhosis.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

Gabapentin

Experimental group

Description:

Patients will receive oral gabapentin 600 mg 1 hour before the surgery.

Treatment:

Drug: Gabapentin

Tramadol

Experimental group

Description:

Patients will receive oral tramadol 100 mg 1 hour before the surgery.

Treatment:

Drug: Tramadol