Preemptive Therapy for High Risk Chronic Lymphoid Leukemia Stage A

French Innovative Leukemia Organisation

Status and phase

Active, not recruiting

Phase 2

Conditions

Chronic Lymphoid Leukemia

Treatments

Drug: Venetoclax

Study type

Interventional

Funder types

Other

Identifiers

NCT03766763

PREVENE FILOCLL10

Details and patient eligibility

About

Open label, single arm, multicenter phase II trial.

Full description

Preemptive therapy with Venetoclax for high risk stage A Chronic Lymphoid Leukemia patients, a phase II trial of the FILO group.

PREVENE (PREemptive VENEtoclax) trial.

Enrollment

82 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Established diagnosis of Chronic Lymphoid Leukemia by International Workshop Chronic Lymphoid Leukemia 2008 criteria with Matutes score Superior to 3, or Matutes score egal to 3 with CD200 positive and CD20 low
High risk Binet stage A, patients presenting at least 2 from 3 risk factors: Lymphocytosis Superior to 13 Giga per liter, CD38 positive, beta2 microglobulin Superior to 2.5 milligram per liter.

Only patients with unmutated status will be treated and followed according to the trial.

No prior chemotherapy, radiation or antibody treatment
Age Superior to 18 years
Life expectancy Superior to 6 months
Performance status 0 to 2
All parameters for risk stratification present
Possibility of follow-up
Adequate hepatic function per local laboratory reference range as follows: Aspartate transaminase and alanine transaminase Superior to 3.0 of upper limit of normal and Bilirubin inferior or egal to 1.5 of upper limit of normal (unless bilirubin rise is due to Gilbert's syndrome or of non-hepatic origin).
Willingness to accept highly effective methods of contraception for the duration of therapy and 12 months thereafter
Women of childbearing potential must have a negative serum (beta-human chorionic gonadotropin) or urine pregnancy test at Screening.
Sign (or their legally-acceptable representatives must sign) an informed consent document indicating that they understand the purpose of and procedures required for the study, including biomarkers, and are willing to participate in the study

Exclusion criteria

Binet Stage A patients with progressive disease according to International Workshop Chronic Lymphoid Leukemia 2008 criteria
Clinically apparent autoimmune cytopenia, in particular antiglobulin test positive hemolytic anemia (positive antiglobulin test without anemia is not an exclusion criteria)
Active secondary malignancy or chemotherapy/radiotherapy for any neoplastic disease other than Chronic Lymphoid Leukemia prior to the study
Medical condition requiring the long term (estimated to be more than one month) use of oral corticosteroids
Patient refusal to perform the bone marrow biopsy for evaluation points
Patients with active bacterial, viral or fungal infection
Subject is known to be positive for Human Immunodeficiency Virus
Evidence of other clinically significant uncontrolled conditions
Treatment with any other investigational agent or participating in another trial within 30 days prior to entering this study
A female patient who is pregnant or breast feeding
Concurrent severe diseases which exclude the administration of therapy
Richter's syndrome
Treatment with any of the following within 7 days prior to the first dose of study drug: Steroid therapy for anti-neoplastic intent, moderate or strong cytochrome P450 3A inhibitors, moderate or strong cytochrome P450 3A inducers
Administration or consumption of any of the following within 3 days prior to the first dose of study drug: grapefruit or grapefruit products, Seville oranges, star fruit.
Prior and concomitant therapy
Malabsorption syndrome or other condition that precludes enteral route of administration
Received a live viral vaccination within 6 months prior to the first dose of study drug. A significant history of renal, neurologic, psychiatric, endocrine, metabolic, immunologic, cardiovascular, or hepatic disease that, in the opinion of the investigator, would adversely affect the patient's participation in this study or interpretation of study outcomes
Major surgery within 30 days prior to the first dose of study treatment
History of prior other malignancy that could affect compliance with the protocol or interpretation of results
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