Prefrontal Cortex and Abstract Thinking

Institut National de la Santé Et de la Recherche Médicale, France

Status: Completed

Conditions: Abstract Thinking; Concept Formation

Treatments: Other: MRI; Behavioral: Neuropsychological examination

Study type: Observational

Funder types: Other

Identifiers

NCT01100281

C09-29

Details and patient eligibility

About

The capacity of concept formation is not well understood, even if a link is supposed with the functioning of the frontal lobes.

Our aim is to better understand the cognitive mechanisms underlying this function and to try to correlate the performance with atrophy of the frontal lobe in neurodegenerative diseases involving this region (frontotemporal lobar degeneration and progressive supranuclear palsy).

Enrollment: 69 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• informed consent signed
• MMSE> 20
• No contra indication to MRI

Exclusion criteria

• MMSE<20

Trial design

69 participants in 3 patient groups

PSP (Progressive supranuclear palsy)

Treatment:

Other: MRI

Behavioral: Neuropsychological examination

FTD (Frontotemporal lobar degenerative)

Treatment:

Other: MRI

Behavioral: Neuropsychological examination

Alzheimer's disease

Treatment:

Other: MRI

Behavioral: Neuropsychological examination