PREG - Offspring: Investigation of Children From Mothers With and Without Gestational Diabetes

University Hospital Tuebingen

Status: Enrolling

Conditions: Offspring Exposed to GDM and Control

Treatments: Other: intrauterine exposure to elevated glucose levels

Study type: Observational

Funder types: Other

Identifiers

NCT04722900

617/2020BO1

Details and patient eligibility

About

Gestational diabetes is the most common complication during pregrancy. With a screening between week 24 and 28 of gestation women with gestational diabetes can be identified and treated. Treatment comprises modification of diet and in some cases taking medication. This treatment lowers undesirable events like macrosomia or premature birth. However, unitl gestational diabetes is diagnosed the fetus is exposed to increased intrauterine glucose levels. The long-term effects of a well-managed gestational diabetes on the development of the offspring is still not well understood. Therefore, the PREG - Offspring study investigates several aspects of development in children from healthy and gestational diabetes mothers until adulthood.

Enrollment: 100 estimated patients

Sex: All

Ages: 6 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• signed informed consent provided by child and parent
• documented oral glucose tolerance test of the mother during pregnancy
• adequate management of gestational diabetes until birth

Exclusion criteria

• severe malformation that makes an examination impossible
• existent of coagulation disorder with increased risk of bleeding after blood sampling

Trial design

100 participants in 2 patient groups

non-GDM

GDM

Treatment:

Other: intrauterine exposure to elevated glucose levels