Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Aga Khan University

Status and phase: Completed; Phase 3

Conditions: Intervertebral Disc Prolapse

Treatments: Drug: Pregabalin; Drug: Gabapentin

Study type: Interventional

Funder types: Other

Identifiers

NCT02120703

173-SUR-ERC-10

Details and patient eligibility

About

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.

The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

Enrollment: 78 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 30-60 years age
• Any gender
• elective micro discectomy for intervertebral disc prolapse

Exclusion criteria

1. micro discectomy at two or more vertebral levels,
2. Instrumentation i.e. pedicle screw fixation, hooks etc.,
3. history of steroids or alcohol use,
4. Multiple co-morbids i.e. renal failure, chronic liver disease,
5. use of anticonvulsant drugs,
6. Spinal deformity,
7. Obesity (BMI >30), 8) inability to understand and respond VAS and

9. patients with known allergy to GABA analogues.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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78 participants in 2 patient groups

gabapentin

Active Comparator group

Treatment:

Drug: Gabapentin

Pregabalin

Active Comparator group

Treatment:

Drug: Pregabalin