Pregabalin Stabilize Cardiovascular Response to Intubation

Fudan University

Status and phase: Completed; Phase 4

Conditions: Effect of Laryngoscopy and Tracheal Intubation

Treatments: Drug: Pregabalin

Study type: Interventional

Funder types: Other

Identifiers

NCT03456947

CWW-PRBL-2017

Details and patient eligibility

About

The purpose of the study is to evaluate whether Pregabalin is safe and effective in stabilizing cardiovascular response to laryngoscopy and tracheal intubation of patients under general anesthesia.

Enrollment: 90 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists(ASA) grade I and II scheduled for elective surgery

Exclusion criteria

• patient refusal.
• patients with serious chronic kidney, liver, lungs, or cardiovascular diseases.
• allergy to any of the study medications.
• patients taking sedation or antihypertensive medications.
• suspected difficult intubation or intubation time more than 22s.
• pregnant or breastfeeding women.
• BMI>30.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups

control group

No Intervention group

Description:

the patients receive routine preoperative preparation without having Pregabalin

Pregabalin150mg group

Experimental group

Description:

the patients receive 150mg pregabalin 60 minutes prior to the surgery

Treatment:

Drug: Pregabalin

Pregabalin300mg group

Experimental group

Description:

the patients receive 300mg pregabalin 60 minutes prior to the surgery

Treatment:

Drug: Pregabalin