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Pregabalin Stabilize Cardiovascular Response to Intubation

Fudan University logo

Fudan University

Status and phase

Completed
Phase 4

Conditions

Effect of Laryngoscopy and Tracheal Intubation

Treatments

Drug: Pregabalin

Study type

Interventional

Funder types

Other

Identifiers

NCT03456947
CWW-PRBL-2017

Details and patient eligibility

About

The purpose of the study is to evaluate whether Pregabalin is safe and effective in stabilizing cardiovascular response to laryngoscopy and tracheal intubation of patients under general anesthesia.

Enrollment

90 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists(ASA) grade I and II scheduled for elective surgery

Exclusion criteria

  • patient refusal.
  • patients with serious chronic kidney, liver, lungs, or cardiovascular diseases.
  • allergy to any of the study medications.
  • patients taking sedation or antihypertensive medications.
  • suspected difficult intubation or intubation time more than 22s.
  • pregnant or breastfeeding women.
  • BMI>30.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

90 participants in 3 patient groups

control group
No Intervention group
Description:
the patients receive routine preoperative preparation without having Pregabalin
Pregabalin150mg group
Experimental group
Description:
the patients receive 150mg pregabalin 60 minutes prior to the surgery
Treatment:
Drug: Pregabalin
Pregabalin300mg group
Experimental group
Description:
the patients receive 300mg pregabalin 60 minutes prior to the surgery
Treatment:
Drug: Pregabalin

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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