Pregabalin Treatment for Trigger Points

Fatih Sultan Mehmet Training and Research Hospital

Status: Completed

Conditions: Myofascial Pain Syndrome

Treatments: Drug: Pregabalin 150mg

Study type: Interventional

Funder types: Other

Identifiers

NCT04600037

FSMEAH-KAEK 2014/20

Details and patient eligibility

About

Myofascial pain syndrome (MPS) is a common problem in the general population. MPS should not be a local/peripheral painful syndrome and considered to be a syndrome of central sensitivity. We aimed to investigate the effect of pregabalin in patients with MPS in this study

Full description

We randomized 40 patients into two groups, and 17 patients per group completed the study. Patients in group I received pregabalin and exercise therapy, whereas those in group II received exercise therapy alone. All patients were evaluated as follows: for pain by VAS; trigger-point pressure pain threshold-(PPT) by algometry; neuropathic pain using DN4 and quality of life with the SF36. Evaluations were performed pretreatment and at the end of the first and third months of treatment.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who diagnosed fibromyalgia syndrome,
• Patients who were also diagnosed as cervical myofascial pain syndrome based on the upper trapezius muscle

Exclusion criteria

• Patients who had received dry needling or local anesthetic injection to trigger point in the dominant upper trapezius muscle within 3 months of the start of the study.
• renal insufficiency,
• impaired liver function,
• malignancy,
• pregnancy
• infections,
• history of drug or alcohol abuse

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Group 1

Active Comparator group

Description:

Patients received pregabalin (target dose 300 mg/day) and exercise therapy (stretching exercises for the trapezius muscle). Patients were instructed to perform 10 repetitions three times a day., 3 months

Treatment:

Drug: Pregabalin 150mg

Group 2

No Intervention group

Description:

Patients received exercise therapy alone (stretching exercises for the trapezius muscle). Patients were instructed to perform 10 repetitions three times a day., 3 months