Pregnancy and Childbirth in Women with Thalassemia Yesterday and Today

Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia

Status: Completed

Conditions: Thalassemia

Study type: Observational

Funder types: Other

Identifiers

NCT06889727

GRAV001

Details and patient eligibility

About

Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children.Since an initial report of a successful pregnancy in a woman with thalassemia major by Walker in 1969, hundreds of pregnancies have been reported so far, highlighting that women carefully managed in the preconception phase usually carry out a successful gestation and labor, both in case of spontaneous conception and assisted reproductive techniques.

Enrollment: 75 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Transfusion dependent and nontransfusion- dependent thalassemia
• Pregnancy ended with the birth of a live or dead foetus
• Pregnancy ended in miscarriage or voluntary abortion
• Pregnancy in progress

Exclusion criteria

• Other types of anemia
• Pregnancy not initiated despite assisted fertilization practices
• Subjects unwilling to sign informed consent