Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)

Stellenbosch University (SU)

Status: Completed

Conditions: Infertility

Treatments: Drug: Human derived FSH

Study type: Interventional

Funder types: Other

Identifiers

NCT00680238

DKotze

Details and patient eligibility

About

Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.

Full description

Comparing pregnancy rates and implantation rates when embryos are selected using the most common criteria for embryo selection on day 3 - the morphology-(number of blastomere, their shape and size and the percentage of fragmentation)vs a graduated embryo score accumulated over 72 hours and the expression of sHLA-G at 44-46 hours post fertilization.

Enrollment: 214 patients

Sex: Female

Ages: 25 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Self paying ART patients

Exclusion criteria

• Abnormal uterus
• Specific Immunologic factors

Trial design

214 participants in 2 patient groups

A

No Intervention group

Description:

Embryo selection for transfer based on a Day 3 score only.

Treatment:

Drug: Human derived FSH

B

Active Comparator group

Description:

Embryos for transfer by first selecting any embryos that had a positive sHLA-G expression of OD = 190 ±6 and correlating such with the highest GES score available.

Treatment:

Drug: Human derived FSH