Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation

Universidade Federal do Rio de Janeiro

Status: Completed

Conditions: Pregnancy

Treatments: Other: Beetroot juice; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03315806

56732216.5.0000.5699

Details and patient eligibility

About

Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.

Enrollment: 12 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gestation between 20 and 35 weeks;
• over 18 years

Exclusion criteria

• diabetes mellitus and gestational diabetes;
• hypertensive syndromes;
• HIV positive;
• liver or kidney disease;
• beetroot allergy;
• use of antioxidants and medicament that alter endothelial function;
• use of antibiotics up to 2 weeks before the visits and using.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Beetroot Juice

Active Comparator group

Description:

Beetroot juice containing 9 mmol of nitrate per dose

Treatment:

Other: Beetroot juice

Placebo juice (nitrate depleted)

Placebo Comparator group

Description:

Beetroot juice nitrate-depleted

Treatment:

Other: Placebo