Pregnancy Rates in Women With Normal Uterine Cavity With and Without Cervical Abnormalities

A

Assiut University

Status

Unknown

Conditions

Intracytoplasmic Sperm Injection ,Hysteroscopicaly Detected Cervical Pathologies

Treatments

Procedure: Office Hysteroscopy

Study type

Observational

Funder types

Other

Identifiers

NCT04536389
pearlstudy

Details and patient eligibility

About

The aim of our study is to investigate the pregnancy rates in women with normal uterine cavity ,with and without cervical abnormalities.

Full description

The cervix is made up of the ectocervix and endocervix and is on average 3-4 cm long and 2.5 cm wide (Pardo et al., 2003; Mazouni et al., 2005; Robert et al., 2013). The ectocervix is the portion of the cervix projecting into the vagina. It is composed of non-keratinized stratified squamous epithelium and is divided into anterior and posterior lips. The squamocolumnar junction is the area where the epithelial cells of the endocervix and ectocervix meet (Herfs et al., 2013). In this area, the columnar cells of the endocervix undergo metaplasia to the squamous cells of the ectocervix. The opening of the ectocervix to the vagina is called the external os. Although studies of cervical length in non-pregnant women are few, it is acknowledged that the size and shape of both the cervix and the external os differ in women (Pardo et al., 2003; Mazouni et al., 2005) and vary with age, hormonal changes, parity and surgical treatments to the cervix. Further evaluation of any cervical abnormalities by hysteroscopy eg. (choronic cervicitis , microcycstic epethelium ,micropolypi , cervical stenosis) before ICSI could address us to a hidden cause of infertility and may improve the pregnancy rates in ICSI cycles with prompt medical or surgical managment of such pathologies.

Enrollment

120 estimated patients

Sex

Female

Ages

18 to 38 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

1. Women between 18 and 38 years old. 2. An indication for IVF/ICSI. 3. Women with primary or secondary infertility. 4. Women with BMI between 20 & 35.

Exclusion criteria

1. Refusal to join the study. 2. Untreated tubal hydrosalpinges. 3. Poor responders as assessed by AFC 4 or less, AMH O.8 ng/dl (nice 2013).

Trial design

120 participants in 2 patient groups

group A
Description:
women with normal uterine cavity and normal cervix by office hysteroscopy.
Treatment:
Procedure: Office Hysteroscopy
group B
Description:
women with normal uterine cavity with hysteroscopically detected cervical abnormality.
Treatment:
Procedure: Office Hysteroscopy

Trial contacts and locations

1

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Central trial contact

Ahmed M. Kamel, MSc&MBBH; Ibrahim I. Mohammed, MD&MSC

Data sourced from clinicaltrials.gov

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