Pregnancy Related Inappropriate Sinus Tachycardia (PRIST)

NHS Foundation Trust

Status

Unknown

Conditions

Pregnancy Related

Inappropriate Sinus Tachycardia

Treatments

Diagnostic Test: Haemodynamic variables

Diagnostic Test: Autonomic Nervous System (ANS) Activity

Diagnostic Test: ECG

Diagnostic Test: heart rate monitor

Other: Echocardiogram

Study type

Observational

Funder types

Other

Identifiers

NCT03317249

PRIST

Details and patient eligibility

About

A feasibility study into the exploration of possible mechanisms underlying inappropriate sinus tachycardia (IST) syndrome in pregnancy.

Full description

This is a non-interventional, physiological study which will explore the feasibility of examining autonomic function and related haemodynamic variables in pregnant women with and without inappropriate sinus tachycardia, with the aim of providing scope for future research.

Sinus tachycardia (normal heart rhythm but fast heart rate) is common and usually related to an obvious cause (e.g. exercise such a running or cycling) and doesn't cause any untoward symptoms. In rare cases however, sinus tachycardia can occur without an obvious cause (i.e. it is inappropriate to the situation) and can cause distressing symptoms such as palpitations, dizziness and breathlessness at rest or with minimal exertion. This syndrome of inappropriate sinus tachycardia is poorly understood and can be difficult to manage; especially when the affected individual is pregnant. In order to understand the condition better and improve care pathways we aim to measure various features of the cardiovascular system in pregnant women with and without IST.

Enrollment

200 estimated patients

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 18-45 years of age
Able to give written informed consent and willing to participate
The participant falls into one of the below categories:

i. Pregnant women with IST ii. Pregnant women without IST

Exclusion criteria

Obesity (BMI > 29.9)
Current or recent (within last 3 months) smoker
Known medical condition likely to affect HRV (other than IST in relevant groups)
Previous history of hypertensive disorders in pregnancy
Lack of written informed consent