Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist

Johns Hopkins Bloomberg School of Public Health

Status: Completed

Conditions: Kidney Failure, Chronic

Treatments: Other: Prehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT02895243

IRB00006786

Details and patient eligibility

About

This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of transplantation.

Full description

Prehabilitation is the enhancement of functional capacity of a patient to improve their ability to withstand a future stressor. The investigators primary objective is to demonstrate feasibility for prehabilitation in Aim 1 and test whether the number of prehabilitation sessions is associated with increased physical activity. The investigators will formally test whether prehabilitation is associated with a reduction in short term and long term KT outcomes as part of Aim 2. The investigators will test whether there is an effect of prehabilitation on short-term (KT length of stay> 2 weeks, early hospital readmission and delayed graft function) and long-term (acute rejection (within the first year), 1 year patient and graft survival) outcomes compared to standard of care controls. Participants will be followed for 3-6 months or until they receive a kidney transplant.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Men and women with end stage renal disease who are within 3-6 months of kidney transplantation and are on the kidney transplant waitlist at Johns Hopkins
2. Must be at least 18 years or older at enrollment
3. Must be English speaking
4. Must be enrolled in an ongoing cohort study of adults with ESRD who are being evaluated for kidney transplantation
5. Must be willing to participate in a prehabilitation program and able to give informed consent

Exclusion criteria

1. Patients who have any of the following medical conditions will be excluded from the study:

   • Active Angina pectoris
   • Chronic lung disease and daily use of oxygen
   • Cerebral vascular disease
   • Musculoskeletal conditions that would limit participation in prehabilitation
   • Lower- or upper-extremity amputation
   • Orthopedic disorders exacerbated by physical activity
   • Decreased mental capacity

2. Patients who live outside of Maryland will not be included in the study.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Prehabilitation

Experimental group

Treatment:

Other: Prehabilitation