Prehabilitation for Ovarian Cancer Patients

Nova Scotia Health Authority (NSHA)

Status

Enrolling

Conditions

Surgical Complication

Treatment Outcomes

Frailty

Ovarian Cancer

Prehabilitation

Enhanced Recovery After Surgery

Exercise

Treatments

Behavioral: Prehabilitation Exercise Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT05364879

NSH Adv Ovarian Cancer Prehab

Details and patient eligibility

About

Individuals with ovarian cancer have very poor survival rates. This is because the cancer is not usually detected until it has reached advanced stages. How long an individual survives also is determined by the cancer treatment they receive. Although there are best treatment practices to improve survival, some women have other conditions that limit treatment options. One such condition seen in as many as 50% of women with advanced ovarian cancer is frailty (an age-related decline in function and health). This is a major concern as doctors will often have to change how the cancer is treated based on the patient being frail. For example, patients living with frailty are less likely to have their full tumor removed during surgery. They are also more likely to have complications with surgery, stay in the hospital longer, and recover less well from surgery overall. Patients living with frailty also are more likely to experience delays in their chemotherapy starting, receive lower doses of chemotherapy and/or receive fewer cycles of chemotherapy. These changes in treatment may decrease how long a patient survives after diagnosis. Thus, research is needed to explore strategies to decrease frailty in patients who require treatment for advanced ovarian cancer. An option gaining more attention is physical exercise (e.g. walking, repeatedly rising from a chair). Exercise performed before surgery, which is called prehabilitation, can improve how well a patient recovers after surgery and increase how long they survive. Research has shown that prehabilitation is very beneficial for patients undergoing surgery for heart disease. However, it is not clear whether prehabilitation works for those with advanced ovarian cancer that are going to have surgery. Therefore, the investigators want to explore how a 4+ week exercise program performed while waiting for surgery for advanced ovarian cancer changes frailty and how a patient recovers after surgery. The investigators will specifically look whether the exercise program: 1) reduces how frail a patient is before surgery; 2) improves how well the patient recovers after surgery; and 3) affects the patient's chemotherapy treatment plan. This study will provide important information about the ability of prehabilitation exercise to improve surgical and treatment outcomes in women with advanced ovarian cancer. Overall, it is believed that exercise has the potential to improve the survival of advanced ovarian cancer patients.

Enrollment

108 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

18 years or older
Have a confirmed diagnosis of stage III or IV ovarian cancer
Scheduled to receive cytoreductive surgery as part of their treatment plan
Must have a minimum of 4-weeks between the time of study enrollment and scheduled surgery
Be able to attend in-person and/or virtual exercise sessions
Be fluent in English
Have oncologist approval

Exclusion criteria

Have already completed surgery
Unstable cardiac or respiratory disease, injury or any other co-morbid disease that may make it unsafe for participants to exercise
Significant cognitive impairment (e.g., do not have the capacity to consent, unable to follow exercise instructions)