Prehabilitation in Esophageal Cancer Care

McGill University

Status: Unknown

Conditions: Esophageal Cancer

Treatments: Behavioral: Prehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT04581005

MUHC 2019-5387

Details and patient eligibility

About

Prehabilitation utilizes the preoperative period to prevent or attenuate the treatment-related functional decline and its consequences. This project aims at testing feasibility and effectiveness of multimodal prehabilitation in esophageal cancer care.

Full description

While evidence on prehabilitation is mounting, upper gastrointestinal surgery still remains under-investigated. This trial aims to explore the effect of prehabilitation over the whole perioperative trajectory, including neo-adjuvant treatment (NAT).

Multimodal prehabilitation includes exercise, nutrition therapy, and mental distress coping strategies. In the context of a multimodal approach, the two groups follow different exercise prescriptions: high-intensity interval supervised training prescribed accordingly cardiopulmonary exercise testing (CPET)-derived variables, versus a home-based program. For both groups, multimodal prehabilitation is prescribed over the whole preoperative period, including during NAT.

Enrollment: 54 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with non-metastatic esophageal cancer undergoing neo-adjuvant chemotherapy and surgery.

Exclusion criteria

• co-morbid medical, physical and mental conditions that contraindicate exercise or oral nutrition

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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54 participants in 2 patient groups

Supervised Prehabilitation

Experimental group

Description:

Prehabilitation will include exercise, nutrition, and anxiety-coping intervention. This group will receive a supervised, in-hospital training.

Treatment:

Behavioral: Prehabilitation

Home-based Prehabilitation

Experimental group

Description:

Prehabilitation will include exercise, nutrition, and anxiety-coping intervention. This group will receive a home-based training.

Treatment:

Behavioral: Prehabilitation