Prehabilitation in Ovarian Cancer Patients During Chemiotherapy Before Cytoreductive Surgery. (PREHONED)

Medical University of Silesia

Status: Invitation-only

Conditions: Ovarian Cancer

Treatments: Procedure: Prehabilitation. An intensive prehabilitation for NACT patients

Study type: Interventional

Funder types: Other

Identifiers

NCT07058753

PREH/2025-2-1 (Registry Identifier)

Details and patient eligibility

About

Prehabilitation includes care for patients preparing for surgery. This is a modern approach aimed at increasing the patient's functional capacity before surgery and improving postoperative results. Prehabilitation includes preoperative physical activity, nutritional intervention, psychological support, cessation of stimulants and optimization of laboratory test results.

Many studies have shown a positive effect of prehabilitation on postoperative results, mainly reducing the number of postoperative complications and shortening the hospitalization time.

The assumed time of prehabilitation is 2-6 weeks, but in the case of oncology patients, the procedure should not be delayed only for the sake of prehabilitation.

Our study includes oncology patients with ovarian cancer who are referred for neoadjuvant chemotherapy before interval cytoreductive surgery. The assumption of the study is an intensive course of prehabilitation during neoadjuvant treatment, which should provide significantly better postoperative results.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with confirmed ovarian cancer
• No possibility of performing primary debulking surgery (Fagotti score > 8 points). Referral patient for neoadjuvant chemotherapy
• Consent to participate in the study
• Age over 18 years

Exclusion criteria

• Performing primary debulking surgery
• Lack of consent to participate in the study
• Aletti score < 4 points in interval debulking surgery
• Severe neurological/psychiatric disorders that make contact with the patient difficult

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Intense course of prehabilitation

Experimental group

Description:

Patients undergoing intense prehabilitation program

Treatment:

Procedure: Prehabilitation. An intensive prehabilitation for NACT patients

Standard preoperative care

No Intervention group

Description:

Patients with standard preoperative care