Prehabilitative Exercise Prior to Immobilization (PREHAB)

Bispebjerg Hospital

Status

Completed

Conditions

Disuse Atrophy

Skeletal Muscle Atrophy

Sarcopenia

Treatments

Other: Prehabilitative exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT06205784

BBH164

Details and patient eligibility

About

This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance exercise training (HReT). Half of the participants (12 younger and 12 older) will also undergo 4 weeks HReT prior to the immobilization. Prehabilitative exercise may confer protective effects on subsequent immobilization, and the various underlying mechanisms involved

Enrollment

64 patients

Sex

All

Ages

20 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age: Between 20-35 years old or between 65-85 years old.
BMI: Between 18.5 and 35 kg/m2.
Healthy and well, with normal dietary habits (not vegan).

Exclusion criteria

More than one muscle biopsy previously taken from both vastus lateralis muscles.
Smoking.
Pregnancy.
Past or present substance or alcohol abuse.
Medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial.
Knee pain that could affect the completion of the training intervention.
High intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger).
Participation in regular strength training within the past year.
Regular participation in structured sports.
Current use of blood-thinning medication.
Previous participation in trials involving oral intake of heavy water.
Metal in the body preventing MRI scanning.
For the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.