Prehospital CPAP vs. Usual Care for Acute Respiratory Failure

Dalhousie University

Status: Completed

Conditions: Respiratory Insufficiency; Hypoxia

Treatments: Device: Continuous positive airway pressure ventilation mask

Study type: Interventional

Funder types: Other

Identifiers

NCT00405314

DAL06-04

Details and patient eligibility

About

The purpose of this study is to evaluate the effectiveness of continuous positive airway pressure ventilation when applied by paramedics to individuals with severe breathing difficulties in the prehospital setting.

Full description

Continuous positive airway pressure ventilation (CPAP) has been shown to be effective in avoiding endotracheal intubation (ETI) for patients with acute respiratory failure in hospital but despite several case series, the effectiveness of the prehospital application of CPAP by paramedics has not been studied in a randomized fashion. We performed a prospective, randomized, non blinded trial to determine whether patients in acute respiratory failure treated with CPAP in the prehospital setting had lower overall ETI rates than those treated with standard care.

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe dyspnea
• respiratory rate >25 breaths/minute
• hemodynamically stable
• able to cooperate with ventilatory support measures
• assessed by paramedics as being in urgent need of ETI and/or manual positive pressure ventilation
• a trip destination of the QEII Health Sciences Center or Dartmouth General Hospital

Exclusion criteria

• require ETI for immediate airway protection
• respiratory rate < 8 breaths/minute
• evidence of hemodynamic instability
• cardiac ischemia
• any chest pain within 3 hours of presentation
• valid "do not resuscitate" advanced directive
• an inadequate supply of portable oxygen

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)