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The goal of this clinical trial is to test if treatment with prehospital Non-invasive ventilation (NIV) for patients with acute respiratory failure (ARF), due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on in-hospital criteria, should be used in the prehospital setting. This is performed with the introduction of prehospital arterial blood gas analyzation. The primary objective is:
• To determine if early prehospital applied NIV together with standard medical treatment will affect arterial pH at hospital arrival in patients with ARF due to AECOPD.
Participants in the intervention will receive Non-invasive ventilation together with standard medical treatment. The intervention will be compared to standard medical treatment alone, that may include inhaled bronchodilators, intravenous corticosteroids, and titrated oxygen supplementation.
Enrollment
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Volunteers
Inclusion criteria
Age greater than or equal to 18 years.
Medical history of COPD.
Unable to give informed consent ("Inhabil" in Danish) based on the criteria below
Respiratory acidosis with a PaCO2 of > 6,0 kPa and a pH of < 7,30.
And one of the following:
Respiratory rate of > 25 per minute.
Hypoxia with a PaO2 < 7 kPa and/or a saturation < 88% without oxygen administered.
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
140 participants in 2 patient groups
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Central trial contact
Jesper H Brendel, MD.
Data sourced from clinicaltrials.gov
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