Preimplantation Genetic Screening in Women Over 35 Year

Catholic University (KU) of Leuven

Status

Completed

Conditions

In Vitro Fertilization

Treatments

Procedure: Preimplantation genetic screening after embryo biopsy

Study type

Interventional

Funder types

Other

Identifiers

NCT00593671

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Details and patient eligibility

About

In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS.

In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.

Enrollment

100 patients

Sex

All

Ages

35 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

All couples with a medical indication for IVF and with a female age of at least 35 years are invited to participate in the study.

Exclusion criteria

Cycles were excluded from the study if ≤ 2 fertilized oocytes were available on day 1 after oocyte retrieval (OR), or if ≤ 2 ≥ 6c stage embryos were available on day 3 after OR.