Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Mass General Brigham

Status

Not yet enrolling

Conditions

Mental Disorder

Cannabis Use Disorder

Depression - Major Depressive Disorder

Treatments

Behavioral: Amplification of Positivity - Cannabis Use (AMP-C)

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT06878859

1K23DA062034 (U.S. NIH Grant/Contract)

2025p000583

Details and patient eligibility

About

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Enrollment

80 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged ≥ 18 years
Resides in the United States
Able to read and understand English and willing to provide informed consent/comply with the study protocol
Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9)
Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R)
Current elevated anhedonia, as indicated by the PHQ-9
Interest in receiving treatment for their cannabis use and depression
Meet criteria for current MDD and CUD per the DSM-5

Exclusion criteria

History of a psychotic disorder or bipolar disorder type I/II
Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale
Current psychotherapy engagement
Changes in psychotropic medication within six weeks of the start of study