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Preliminary Study of a Vaginal Lubrication Ring to Treat the Symptoms of Vaginal Dryness

J

J3 Bioscience

Status and phase

Completed
Early Phase 1

Conditions

Atrophic Vaginitis
Menopausal and Perimenopausal Disorder, Unspecified

Treatments

Device: Vaginal Lubrication Ring for Vaginal Dryness

Study type

Interventional

Funder types

Other
Industry

Identifiers

Details and patient eligibility

About

This is a pilot study, assessing the ability and safety of the use of VR101 intravaginal ring to relieve the symptoms of vaginal dryness, in peri and post-menopausal women. VR1010 is designed to release glycerol. The study will assess the duration of lubrication/ moisturization of the vagina with the VR101 intravaginal ring in place (up to 7 days) and participant satisfaction of the device.

Study participants will insert the intravaginal ring and leave it in place for an initial 7 days and then repeat this process a 2nd time. Participants will respond to questionnaires, complete a daily diary and come in for 4 separate study visits. Each study visit will involve a brief vaginal exam.

Upon removal of the initially inserted device (7 days after first study visit), participants will insert a second device for an additional 7 days and undergo the same evaluation.

Full description

Vaginal dryness affects many women, although they frequently do not bring up the topic with their doctors. Vaginal dryness can dramatically affect women's lifestyle, in particular their sexual activity and relationship with their partner. Since we believe that living with uncomfortable vaginal dryness does not have to be part of aging, we intend to conduct this study to evaluate a lubricating vaginal ring developed to ease symptoms caused by vaginal dryness.

The objectives of this study are to obtain preliminary data on the ability of the VR101 intravaginal ring to relieve the symptoms of vaginal dryness in peri- and post-menopausal women. Effectiveness will be measured in two ways:

  1. Vaginal health index scoring assessed by a member of the research team
  2. Participant answers to questionnaires

Study objectives will assess the following:

  1. Successful placement of VR101 intravaginal ring into the vagina
  2. Ease of insertion and removal
  3. Comfort and fit
  4. Lubrication/ moisturization of the vagina

Enrollment

21 patients

Sex

Female

Ages

35+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Signed informed consent
  • Females over 35 years of age at the time of enrollment
  • Willing to comply with study visit schedule
  • Self-reported peri- or post-menopausal women with self-reported vaginal dryness
  • Willing to abstain from vaginal intercourse while in the study

Exclusion criteria

  • Use of hormone therapy
  • Undergoing any vulvar or vaginal procedures (biopsies, radiation in the last 3 months)
  • Active vulvar or vaginal injections/lesions or complaints, as well as undiagnosed abnormal genital bleeding
  • History of chronic pelvic pain, interstitial cystitis, vulvar vestibulitis, pelvic inflammatory disease within the past 12 weeks
  • Known current clinically evident cervical or vaginal infection
  • Postpartum or post-abortion endometritis, unless symptoms resolved at least 12 weeks prior to study entry
  • Current persistent, abnormal vaginal bleeding
  • History of inability to place an IVR
  • History of any abnormality of the vagina resulting in distortion of the vaginal canal or incompatible with IVR placement
  • Body habitus, or history of lower genital tract abnormalities or prior surgeries, which may not allow the vagina to be appropriately accessed
  • Known or suspected allergy or hypersensitivity to polyurethane or glycerol
  • Known current alcohol or illicit drug abuse
  • Participants who have not recovered from adverse events due to chemotherapy or radiation treatment for cancer
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Any condition that, in the opinion of the investigator or study staff that would constitute contraindications to participation in the study or would compromise ability to comply with the study protocol

Trial design

Primary purpose

Supportive Care

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

21 participants in 1 patient group

Single Arm Study
Other group
Description:
Vaginal Lubrication Ring for Vaginal Dryness
Treatment:
Device: Vaginal Lubrication Ring for Vaginal Dryness

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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