Preload Dependence During Prone Position In ARDS Patients (PRD-ARDS-PP)

Civil Hospices of Lyon

Status: Completed

Conditions: ARDS PATIENTS WITH HEMODYNAMIC INSTABILITY

Treatments: Procedure: Trendelenburg position

Study type: Interventional

Funder types: Other

Identifiers

NCT01965574

2012.783

Details and patient eligibility

About

Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.

Enrollment: 33 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS patient
• mechanically ventilated in prone position
• sedated and paralyzed
• with continuous cardiac output monitoring by transpulmonary thermodilution and pulse contour analysis
• fluid loading as indicated by attending physician

Exclusion criteria

• Age below 18
• no affiliation to social security
• Vena cava obstruction
• previous inclusion in protocol

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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33 participants in 1 patient group

Single arm

Experimental group

Treatment:

Procedure: Trendelenburg position