Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres (PreDeARM)

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Coronary Artery Disease; Pulmonary Atelectasis; Hypovolemia; Anesthesia, General; Coronary Artery Bypass

Treatments: Other: flotrac measurement; Other: tee measurement; Other: clearsight measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT02678559

CHU-0254

Details and patient eligibility

About

The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE). These variations will be measured on preload dependency or preload independency status. The principal purpose is to determine if variations of stroke volume during standardized ARM can predict the preload dependency status.

Full description

Population studied: anesthetized patients for cardiac surgery of coronary bypass.

Secondary endpoints : - comparison between TEE and mini-invasive monitoring systems in accuracy of measurement of stroke volume variation during ARM. These mini-invasive systems are : Clearsight system (Edwards Lifescience) and Flotrac system (Edwards Lifescience)

• Difference between pre and post-cardiopulmonary bypass status on principal purpose evaluation

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient Undergoing a surgical procedure of coronary artery bypass, with cardiopulmonary bypass Written consent collected

Exclusion criteria

• Emergency case
• Pericardial effusion
• Aortic or mitral valvulopathy
• Contraindication for : TEE, alveolar recruitment manoeuvre (emphysema, pneumothorax, hemodynamic instability), Ringer Lactate solution infusion
• Bad echogenicity
• Patient refusal to participate to the study
• No health insurance

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

TEE monitory system

Experimental group

Description:

comparison between TEE and mini-invasive monitoring systems in accuracy of measurement of stroke volume variation during ARM.

Treatment:

Other: clearsight measurement

Other: flotrac measurement

Other: tee measurement

mini-invasive monitoring system

Experimental group

Description:

comparison between TEE and mini-invasive monitoring systems in accuracy of measurement of stroke volume variation during ARM.

Treatment:

Other: clearsight measurement

Other: flotrac measurement

Other: tee measurement