Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

Damanhour Teaching Hospital

Status and phase: Enrolling; Phase 4

Conditions: Hypotension Drug-Induced

Treatments: Drug: Atenolol Succinate Oral Tablet; Drug: Metoprolol Succinate Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT04914234

DTH: 21002

Details and patient eligibility

About

Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.

Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.

Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

Enrollment: 60 estimated patients

Sex: All

Ages: 21 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status ≤ II
• Age from 21 to 50 years

Exclusion criteria

• ASA physical status > II
• Age < 21 years or > 50 years
• Pregnant women
• Breastfeeding
• Bronchial asthma
• Chronic obstructive pulmonary disease
• Diabetes Mellitus
• Hypertension
• Ischemic heart disease
• Rheumatic heart disease
• Heart failure
• Heart block
• Sick sinus syndrome
• Sinus bradycardia
• Chronic hypotension
• Anemia (Hb < 10 g/dl)
• Renal or hepatic dysfunction
• Central nervous system disease
• Allergic fungal sinusitis
• Patients on beta-blockers
• Alcohol or drug abuse
• Anticoagulation therapy,
• Bleeding diathesis
• Agents influencing autonomic nervous system
• Allergy to the study drugs
• Any contraindication of oral intake

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

Group A (n=30)

Active Comparator group

Description:

Atenolol group

Treatment:

Drug: Atenolol Succinate Oral Tablet

Group M (n=30)

Active Comparator group

Description:

Metoprolol group

Treatment:

Drug: Metoprolol Succinate Oral Tablet