Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Nantes University Hospital (NUH)

Status

Not yet enrolling

Conditions

Frontal Variant of Alzheimer Disease

Bipolar Disorder

Behavioral Variant of Frontotemporal Disorder (bvFTD)

Phenocopy Frontotemporal Dementia (phFTD)

Treatments

Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

Other: Submission of the NEO-PI-3 questionnaire

Study type

Observational

Funder types

Other

Identifiers

NCT06059313

RC23_0343

Details and patient eligibility

About

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility.

The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Enrollment

120 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
Score for Mini-mental state examination ≥ 18
Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset.
Patient and caregiver consents (no opposition)

Exclusion Criteria :

Patient with no caregiver
Pregnant or breast feeding women

Trial design

120 participants in 4 patient groups

Behavioral variant of frontotemporal disorder (bvFTD)

Description:

A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia

Treatment:

Other: Submission of the NEO-PI-3 questionnaire

Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

Phenocopy frontotemporal dementia (phFTD)

Description:

A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.

Treatment:

Other: Submission of the NEO-PI-3 questionnaire

Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

Frontal variant of Alzheimer disease

Description:

A group of participants who fulfill Ossenkopele criteria (2022)

Treatment:

Other: Submission of the NEO-PI-3 questionnaire

Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

Bipolar disorder

Description:

A group of participants who fulfill CIM 10 criteria